Chlorophosphoramidate Morpholino Monomers

These are specific derivatives of morpholino monomers that incorporate a chlorophosphoramidate linkage at the 3' end of the morpholino ring. This chemical modification is crucial because it allows for the subsequent attachment of phosphorodiamidate linkages during the synthesis of Phosphorodiamidate Morpholino Oligonucleotides (PMOs).

Chlorophosphoramidate morpholino monomers, offer several advantages in the context of synthesizing phosphorodiamidate morpholino oligonucleotides (PMOs) and their application as antisense therapeutic agents.