Morpholino Monomers

Adenine, cytosine, guanine, and thymine are nucleotide bases commonly used in nucleic acid synthesis. In the context of morpholino oligomers, these bases are modified to incorporate a morpholine ring instead of a ribose or deoxyribose sugar. This modification provides structural stability and alters the hydrogen bonding properties of the nucleobases.

Morpholino monomers are essential building blocks for the synthesis of chlorophosphoramidate morpholino monomers. These chlorophosphoramidate morpholino monomers, in turn, enable the synthesis of PMOs, which are advanced antisense oligonucleotide therapeutics capable of specifically targeting RNA molecules to modulate gene expression for therapeutic purposes.